Gut Microbiota Bioinformatics Services


Gut Microbiota Bioinformatics Services

The human gastrointestinal tract is colonized by a vast array of microbes, which form communities of bacteria, viruses and microbial eukaryotes. The intestinal microbiota is recognized to play pivotal roles in maintaining human health, and it is involved in many pathogenesis procedures. The human gut microbiota is highly variable from one person to another, which can be massively influenced by ages, diet habits, and health conditions. Understanding how the gut microbiota colonizes, varies and interacts with the host, and even how to associate with diseases can be of great value in the treatment of these diseases, such as inflammatory bowel disease (IBD), diabetes, mental disorders, and cancers.

As many of the traditional methods are both inefficient and uninformative, the statistical and computational techniques based on the big data accumulated by the high-throughput techniques can largely facilitate the progress of the studies of the microbiota. And even more excitingly, benefitting from the rapid development of artificial intelligence, computational methods and the massive database that we already got, researchers can work to their utmost and develop new models for the fields of microbiota-related issues especially human health, and even shed new light upon disease treating methods.

Bioinformatics Analysis

Creative Proteomics as a preeminent corporation that specializes in multi-omics and equipped with state-of-the-art techniques and bioinformatics platforms, as well as well-experienced scientists, provides comprehensive and delicate bioinformatics services for your gut microbiota research. The custom bioinformatics services that we offer cover the whole range of multi-omics, which includes metagenomics, metatranscriptomics, metaproteomics, and metabolomics. We offer bioinformatics processing and statistical analysis include but not limited to:

Metagenomics and Metatranscriptomics Analysis

◆ Preprocessing and quality control filtering
◆ Operational taxonomic unit (OTU) binning
◆ Taxonomy assignment
◆ Abundance table construction
◆ Compositional data analysis (CoDA)
◆ Normalization        
- Relative abundances computation
- Rarefaction
◆ Phylogenetic analysis
◆ Diversity analysis
- Alpha-Diversity
- Beta-Diversity
◆ Ordination
- Principal coordinates analysis (PCoA)
- Non-metric multidimensional scaling (NMDS)
◆ Multivariate differential abundance testing
◆ Univariate differential abundance testing
◆ Data annotation
◆ Microbial signatures
◆ Biomarker discovery
◆ Exploratory statistical analysis
◆ Functional interpretation

Metaproteomics Analysis

◆ Protein database searching and annotation
◆ Quantitative taxonomic analysis
◆ Phylogenetic analysis
◆ Statistical analysis
◆ Functional annotations
◆ Metabolic pathways linking analysis

Metabolomics Analysis

◆ Statistical analysis        
- Univariate analysis
- Multivariate analysis
- High-dimensional feature selection
- Clustering
- Supervised classification
◆ Metatolite set enrichment analysis (MSEA)
◆ Pathway analysis
◆ Time series and Two-factor data analysis
- interactive 3D PCA visualization
- two-way heatmaps with hierarchical clustering
- two-way ANOVA for univariate two-factor analysis
- multivariate empirical Bayes time-series analysis (MEBA)
- ANOVA-simultaneous component analysis (ASCA)
◆ Biomarker analysis
◆ Sample size and power analysis

Coupled state-of-the-art techniques with powerful analysis platforms that carry abundant analytical tools and sophisticated pipelines, we have full capability of exploring the taxonomic and functional compositions of gut microbial communities that play crucial roles in human health. Correspondingly, we provide comprehensive and delicate bioinformatics services for your gut microbiota research in order to bring more blessings for our future. To find more about our bioinformatic services to meet your specific needs, please feel free to contact us!

For Research Use Only. Not for use in diagnostic procedures.

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