Gut Microbiota and Cancers


Gut Microbiota and Cancers

The traditional research on the causes of cancer generally focuses on genes and environmental matter such as cancer-causing substances, diet and exercise, radiation, hormones, and autoimmune diseases. Over the last decade, numerous studies highlighted the dual role of the gut microbiota in preserving host's health, and recent achievements have contributed to the growing consensus that the gut microbiota is linked to cancers. The microbiota that colonizes in the gastrointestinal tract is composed of millions of microorganisms and contributes to balancing the immune system to regulate and maintain host homeostasis. The crosstalk between gut microbiota and the host bidirectionally affects the physiological function across microbiota-gut-organ axes where microbiota composition and metabolism play a pivotal role and gut microbiota can function as both tumor-suppressor and tumor-promoter. Studying the microbiota helps researchers understand the role it plays in the process of carcinogenesis, and this knowledge can lead to novel ways of preventing and treating the cancers and improve public health.

Creative Proteomics is a preeminent corporation that specializes in multi-omics. Equipped with cutting-edge techniques and served by well-experienced scientists, we have extensive experience to assist you in discovering the correlation between gut microbiota and cancers, developing promising ideas into cancer diagnostics, therapeutics, and vaccines. We provide abundant research solutions for various microbiota related cancer models in both model animals and human, including:

◆ Bladder cancer
◆ Brain cancer
◆ Breast cancer
◆ Cervical cancer
◆ Colorectal cancer
◆ Esophageal cancer
◆ Hematologic cancer
◆ Gastric cancer
◆ Kidney cancer

◆ Liver cancer
◆ Lung cancer
◆ Melanoma & metastatic melanoma
◆ Non-small cell lung cancer
◆ Ovarian cancer
◆ Pancreatic cancer
◆ Prostate cancer
◆ Skin cancer
◆ Other cancers

We present rigorous and comprehensive schemes based on multi-omics technologies and powerful bioinformatics platforms to bring novel perceptions into cancer studies by approaches such as gut microbiota composition, essential metabolites, and pathology studies. More specifically, we provide solutions that shed light upon hot topics of cancer research including but not limited to:

Microbiota promotes the process of carcinogenesis

◆ Microbes that negatively affect the host's metabolism or the host's gut and immune system functionalities;
◆ Microbes that interfere with the host's hormones metabolism
◆ Gut microbiota modulates host's cellular proliferative and pro-survival pathways;
◆ Gut microbiota induced cancer transformation;
◆ Gut microbiota induced oxidative stress that may lead to cell-autonomous genomic mutations;
◆ Microbes that stimulate cancer formation by blocking immune-effectors;

Microbiota suppresses cancer procession & Novel therapeutic approaches

◆ Microbes-derived molecules show an anti-tumor activity, such as SCFAs;
◆ Probiotics protect against gut dysbiosis;
◆ Probiotics enhance the host's immune defense mechanisms.

Creative Proteomics dedicates to providing the highest level of solutions in gut microbiota research. We will offer the most suitable strategies according to your sample and research purpose. Our specialty covers the full range of multi-omics including metagenomics, metatranscriptomics, metaproteomics, and metabolomics, coupled with powerful bioinformatics platforms, and other practical tools and resources, we provide the most comprehensive gut microbiota research solutions you will ever get. And we would be more than happy to assist in uncovering the tight association between gut microbiota and tumorigenesis, as well as gut microbiota and anti-cancer therapy. To find out more solutions for gut microbiota and autoimmune disorders, please feel free to contact us.

*For Research Use Only. Not for use in diagnostic procedures.

Microbiome Service
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Expires: Nov.15 — Dec.5, 2021

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