The human gastrointestinal tract is colonized by a dense population of microbes that outnumber host cells 10-fold, which form communities of bacteria, viruses and microbial eukaryotes that are specific to people of different ages, diet habits, and health conditions.
The composition of human gut microbiota changes prominently with age, there are clear differences in the composition of gut microbiota among infants, toddlers, adults and the elderly. Gut microbiota composition of newborns is dramatically shaped by the mode of birth and the mother's microbiota, and later varies depending on what the infant is fed on, a significant shift will occur when the infant transitions to a more solid and varied diet. The gut microbiota composition is quite unstable during infanthood and early childhood. Then microbiota becomes more stable under routine and health conditions during adulthood and contributes to cellular and tissue homeostasis. The microbiota of older people displays greater inter-individual variation than that of younger adults.
Figure 1. The gut microbiota undergoes dynamic changes during host aging. (Aleman 2019)
Creative Proteomics is a preeminent corporation that specializes in multi-omics. Equipped with state-of-the-art techniques and served by well-experienced scientists, we have extensive experience dealing with all kinds of difficulties you may have encountered in your research, and we will provide the most valid solutions to meet your needs. The current multi-omics era promises rapid progress at the global level towards understanding the causes leading to the changes in microbiota composition and function during host aging. We provide powerful tools to support your gut microbiota and host age research from the following multiple views:
Gut Microbiota Composition:
We provide a wide range of technologies for gut microbiota composition profiling. Our specialty lies in multi-omics analysis mainly by state-of-the-art detecting methods coupled with bioinformatics analysis platforms. We provide all kinds of sequencing and gene array technologies to profile target sequences, (meta)genome, and (meta)transcriptome of all types of microbes, in order to offer the most comprehensive information on how the microbiota changes over a lifetime.
- Amplicon sequencing
- Whole-genome sequencing
- Metagenomic sequencing
- Virome sequencing
- DNA microarray
- Metatranscriptomics solutions
Gut Microbiota Metabolism:
Proteins and metabolites are critical indicators to investigate gut microbiota physiological activities within different-aged hosts. We provide functional analysis of proteins, peptides, and all kinds of intestinal metabolites by cutting-edge technologies including high-performance liquid chromatography (HPLC), nuclear magnetic resonance (NMR) spectroscopy, mass spectrometry (MS) and many other efficient equipment, in order to investigate the physiological status of both the microbiota and the hosts, identify various potential biomarkers, map unique metabolome fingerprints of specific cellular processes, determine specific pathways, and unveil fundamental mechanisms of certain diseases.
Link with Fitness and Diseases:
The advance of multi-omics applied in gut microbiota facilitates the studies of the link between gut microbiota and the onset of age-related diseases that may including cancer, obesity, diabetes, and inflammatory bowel disease (IBD). And there are more exciting applications to explore – such as if the microbiota participates in triggering host aging or exacerbating the cellular, tissue, and systemic changes that occur during host aging, then it is possible to slow down the process or attenuate aging-related pathologies by targeting the related microbes. We provide solutions including comprehensive multi-omics techniques, powerful bioinformatics, and a variety of model organisms to address these issues:
Creative Proteomics dedicates to providing the highest level of service in gut microbiota research. We will offer the most suitable strategies according to your sample and research purpose. To find out more about the services we offer for gut microbiota and host age research, please feel free to contact us.
1. Aleman FDD, Valenzano DR. Microbiome evolution during host aging. PLOS Pathogens. 2019, 15(7).
For Research Use Only. Not for use in diagnostic procedures.
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- 16S/18S/ITS Amplicon Sequencing
- Gut Microbiota Whole Genome Sequencing
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- CRISPR/Cas9 Gene Editing Service
- Model Organisms for Gut Microbiota Research
- RNAi Service
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- Flow Cytometry (FCM)-Based Analysis and Sorting Services
- Gut Microbiota Fluorescent in situ Hybridization (FISH) Service
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- Microfluidics Services for Gut Microbiome Research
- Western Blot Service for Gut Microbiome Research
- Gut Microbiota Genomic Services
- Gut Microbiota and Host Homeostasis
- Gut Microbiota and Diseases
- Gut Microbiota in Therapeutic and Diagnostic Research
- Targeted Monitoring of Gut Microbiota