Gut Microbiota and Host Homeostasis


Gut Microbiota and Host Homeostasis

Many compare the gut microbiota to a hidden organ that even has a much larger genetic variety than the genome of the host. The microbiota colonized in the gastrointestinal tract composes of an abundant and diverse population of microbes including bacteria, viruses, and microbial eukaryotes. The gut microbiota systemically integrates into the host biology and plays an instrumental role in the homeostasis of the host by bidirectionally affecting physiological processes across the many 'axes' that gut microbiota allies with different organs and systems, these various processes include immune modulation, neurotransmitter regulation, hormones secretion and regulation, and the production of many antioxidants and metabolites. Under normal conditions, the gut microbiota is non-pathological and help the host body maintain homeostasis, and in addition to metabolic benefits, symbiotic bacteria benefit the host with various functions like inhibiting the colonization by other pathogenic microorganisms, while the dysbiosis can result in miscellaneous pathological conditions.

The commensal homeostasis of gut microbiota-host under the intervention. - Gut Microbiota and Diseases

Figure 1. The commensal homeostasis of gut microbiota-host under the intervention. (Zhang 2018)

Our knowledge about the intrinsic mechanisms of the gut microbiota-host interaction and potential therapeutic options for gut microbiota-associated diseases are just starting to take shape, and the current multi-omics era promises rapid progress at the global level towards these research topics.

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Creative Proteomics dedicates to providing the highest level of solutions in gut microbiota research. We will offer the most suitable strategies according to your sample and research purpose. Our specialty covers the full range of multi-omics including metagenomics, metatranscriptomics, metaproteomics, and metabolomics. Coupled with bioinformatics tools and other essential biological tools such as the complete series of model animals, the powerful and currently popular CRISPR/Cas9 technologies, we will provide the most comprehensive gut microbiota research solutions you will ever get. And we would be more than happy to assist your research into gut microbiota projects and promote the health and wellbeing of mankind. To find out more solutions for gut microbiota and diseases, please feel free to contact us.


1. Zhang P; et al. Commensal Homeostasis of Gut Microbiota-Host for the Impact of Obesity. Frontiers in Physiology. 2018, 8:1122.

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