The mammalian gastrointestinal (GI) tract is colonized with an enormous and complex community of gut microbiota. This commensal flora community with its host extensively and provides benefits to its host in many ways, including, but not limited to, nutrients production, protection against pathogens invasion and regulation of immune system.
The immune system plays a vital role in keeping the body healthy by providing a fine balance between the elimination of invading pathogens and the maintenance of tolerance to healthy self-tissue. However, in the case of patients with autoimmune disorders, the mechanism to maintain self-tolerance fails and the result is that the immune system mistakenly attacks and destroys healthy self-tissue.
Given the intimate interplay between gut microbiota and the host immune system, it is not surprising that some members of the gut microbiota have been linked to autoimmune diseases. However, only recently has the study of the gut microbiota and autoimmunity become a more navigable field, owing to the ground-breaking advances in “next-generation” sequencing technology, which have now provided culture-independent microbial analysis that greatly facilitates the characterization of these complex commensal communities. Additionally, extensive progress has been made as investigators have begun to reveal the cellular and molecular interactions between commensals and the mucosal immune system, particularly with the help of animal autoimmune models.
Figure 1. How microbiota shape host immunity1
Creative Proteomics has been focused in the gut microbiota field for years with our continued efforts in providing the most complete and advanced solutions to help our clients achieve their goals in gut microbiota research. The advancing field of host-microbiota interaction, with particular focus on the role of gut microbiota in immune homeostasis and autoimmune diseases both within and outside the intestine.
|Gut microbiome profiling||16S/18S/ITS Amplicon Sequencing|
|Functional analysis of gut microbiome||Gut Metatranscriptomics Sequencing|
|Gut Metaproteomic Analysis|
|Gut Metabolomics Analysis|
|Multi-omics analysis and customized data analysis||The in-depth analysis of multi-omics data can provide a comprehensive understanding of host immune system and gut microbime interactions.|
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1. Hooper LV, Littman DR, Macpherson AJ. Interactions between the microbiota and the immune system. Science. 2012;336(6086):1268–1273. doi:10.1126/science.1223490.
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