The gastrointestinal tract is host to an abundant and diverse population of microbes that are well known to regulate and maintain host homeostasis including metabolism and immune function. Change in stability and diversification of gut microbiota can induce the progression of many metabolic diseases such as obesity, diabetes, cardiovascular diseases, and liver diseases. Therefore, it is of great significance to study the correlation between gut microbiota and host diseases, which is helpful to shed light on not only the role of gut microbiota in the pathogenesis but novel approaches to cure these diseases. Coupled state-of-the-art multi-omics technologies and human and animal model studies, it facilitates the understanding of the qualitative and quantitative alterations of gut microbiota composition that can affect intestinal barrier, immune regulation, substance metabolism, nutrient absorption, energy distribution, etc. and clarifies either a pathogenic or protective role that intestinal commensal microbe species may play in the development of metabolic diseases.
The gut microbiome functions like an active metabolic organ contributing to nutrient digestion and absorption, immune function, and metabolic activity necessary for health. But when a disturbance occurs to microbiota composition, it could affect the host in many ways such as causing dysbiosis, arousing immunologic response, and influencing host metabolism, which almost impacts all systems in the body. From a metabolism perspective, gut microbiota can regulate lipid accumulation, lipopolysaccharide content and the production of short-chain fatty acids, inflammatory response, insulin signaling, etc. We provide research solutions for all kinds of gut microbiota related metabolic disorders include:
◆ Type II Diabetes
◆ Adipose Tissue Inflammation
◆ Alcoholic Liver Disease (ALD)
◆ Alcoholic Steatohepatitis (ASH)
◆ Nonalcoholic Fatty Liver Disease (NAFLD)
◆ Nonalcoholic Steatohepatitis (NASH)
◆ Cardiovascular Diseases (CVD)
◆ Other Metabolic Disorders
The association between alternation of gut microbial composition and metabolic diseases strongly indicates that gut microbiota should be considered as a pivotal factor to modulate host metabolism and metabolic disorders, and methods should be taken to intervene in the pathogenic procedures. Multiple strategies have the potential of modulating gut microbiota such as antibiotics, probiotics, prebiotics, symbiotics, and microbiota transplantation, which have diverse effects on body metabolism and on the development of metabolic disorders. The advances of technology have allowed the attempt at a systematic gut microbiota study, giving more realistic information about its composition, its pathological variance, and corresponding therapeutic approaches.
Creative Proteomics is a preeminent corporation that specializes in multi-omics. Equipped with cutting-edge techniques and served by well-experienced scientists, we have extensive experience dealing with all kinds of difficulties you may have encountered in your research, and we will provide the most valid and state-of-the-art solutions to meet your needs – We can help you raise understanding of the role of the microbiota and allowing for further research; we can provide insight into which features and what contributions the microbiota make that are essential to host physiology; we can assist you in explaining the mechanisms that microbiota interacts with the host; we can combine the basic research with exploring therapeutic methods that target at gut microbiota…
We dedicate to providing the highest level of solutions in gut microbiota research. We will offer the most suitable strategies according to your sample and research purpose. Our specialty covers the full range of multi-omics including metagenomics, metatranscriptomics, metaproteomics, and metabolomics, coupled with powerful bioinformatics platforms, and other practical tools and resources, we provide the most comprehensive gut microbiota research solutions you will ever get. To find out more solutions for gut microbiota and gastrointestinal diseases, please feel free to contact us.
For Research Use Only. Not for use in diagnostic procedures.